Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

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Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

Mesial temporal lobe epilepsy (mTLE) is the most common focal epilepsy in adults and is often refractory to medication. So far, resection of the epileptogenic focus represents the only curative therapy. It is unknown whether pathological processes preceding epilepsy onset are indicators of later disease severity. Using longitudinal multi-modal MRI, we monitored hippocampal injury and tissue reo...

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ژورنال

عنوان ژورنال: eLife

سال: 2017

ISSN: 2050-084X

DOI: 10.7554/elife.25742